![]() Clinical features and predictors of atrial fibrillation in patients with light-chain or transthyretin cardiac amyloidosis. Atrial fibrillation and subtype of atrial fibrillation in cardiac amyloidosis: Clinical and echocardiographic features, impact on mortality. Clinical Importance of Left Atrial Infiltration in Cardiac Transthyretin Amyloidosis. Brief report: Atrial systolic failure in primary amyloidosis. Systemic cardiac amyloidoses: Disease profiles and clinical courses of the 3 main types. Ventricular tachyarrhythmias and sudden cardiac death in light-chain amyloidosis: A clash of cardio-toxicities? Br. Features of atrial fibrillation in wild-type transthyretin cardiac amyloidosis: A systematic review and clinical experience. Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis. Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis. Echocardiographic phenotype and prognosis in transthyretin cardiac amyloidosis. Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction. Atrioventricular Conduction DiseasesĪF = atrial fibrillation AL = light-chain amyloidosis ATTR = transthyretin-related amyloidosis AVN = atrioventricular node CA = cardiac amyloidosis CMR = cardiac magnetic resonance DCCV = direct current cardioversion HV = Hiss-ventricle HF = heart failure HFpEF = heart failure with preserved ejection fraction ICD = implantable cardioverter defibrillator INR = international normalized ratio LA = left atrium LV = left ventricle NOACs = novel oral anticoagulants NSVT = non-sustained ventricular tachycardias NYHA = New York Heart Association PEA = pulseless electrical activity PM = pacemaker SR = sinus rhythm TEE = transesophageal echocardiography TIA = transient ischemic attacks VAs = ventricular arrhythmias VKA = vitamin K antagonist VT = ventricular tachycardia wtATTR = wild-type transthyretin-related amyloidosis. Moreover, the presence of AF in both solely HFpEF and CA may worsen HF symptoms, probably due to the loss of LV filling mediated by the atrial kick. As happens in CA, the presence of diastolic dysfunction and elevated LV filling pressure contributes to LA enlargement and electrical remodeling and eventually leads to AF. Furthermore, HFpEF and AF feed off each other. While in CA, the deposition of amyloid fibrils plays a pivotal role, in patients with solely HFpEF, systemic inflammation and metabolic disorders may lead to microvascular dysfunction and fibrosis of both atria and ventricles, which in turn trigger diastolic dysfunction and AF. As in cardiac amyloidosis, AF and HFpEF are manifestations of a common atrial and ventricular myopathy. Furthermore, as we have seen in wtATTR, two-thirds of patients with solely HFpEF experience AF over time. Indeed, patients with AF present a 4.8 times higher risk of developing HFpEF compared to patients in sinus rhythm, and the prevalence of AF in HFpEF is high, ranging between 15% and 41%. ![]() In these cases, we actively try to identify evidence for anticoagulation treatment, i.e., reducing the interval between Holter ECG evaluations, implanting a loop recorder or providing a home monitoring device for patients with a pacemaker or ICD, and, when renal function allows us, we repeat cardiac magnetic resonance with the aim of atrial thrombus identification.Ītrial fibrillation and HFpEF are strictly related and considered “vicious twins”. These conditions raise many concerns about the risk of thrombus formation. In a few patients, these features are associated with the presence of a clear P wave on the electrocardiogram (in the absence of a clinical history of AF). Atrial standstill might be defined by the absence of mechanical activity in the atria, as assessed visually at echocardiography, or by using atrial strain, and it might be associated with the presence of a low mitral inflow A-wave amplitude. During follow-up evaluation, it is not infrequent to identify patients presenting severe atrial enlargement or “atrial standstill” or the presence of spontaneous echo contrast within the atria at echocardiography. ![]()
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![]() As many historical plays do, this one has limited used for its female characters with Margaret Cabourn-Smith and the others often relegated to secretarial or long-suffering wife roles, references to period sexism, and the straight-to-audience explorations of the technical breakthroughs of The Goon Show, but they and the rest of the supporting cast still shine in their straight historical and more clownish composite characters.Īs befits a show about a technical innovator, the play makes good use of its space, with Katie Lias’s set creating depth through multiple rooms behind glass, to evoke studio recording areas and flashbacks to performances, nightmares and the battlefields of World War II. Stars Robert Wilfort (Spike Milligan), Patrick Warner (Peter Sellers), and Jeremy Lloyd (Harry Secombe) play perfectly their historical counterparts, their passing physical resemblance bolstered by clothing, props and performances which evokes without slavishly imitating. Milligan struggled throughout his life with the repercussions of his war service and his bipolar disorder, and this play is a glimpse into him through a specific period of his life, the script by Ian Hislop and Nick Newman recreating him through a dramatic ten-year episode (and, many would say, career peak), and using his own brand of comedy (sometimes through verbatim quotation and sometimes through imitation) rather than the oft-used and misused technique of simply speeding through a cradle-to-grave narrative. Though its other chief claim to fame is as an early notable leading role for Peter Sellers, who would later star in the Pink Panther series, amongst other things.īut this play, produced by Karl Sydow, Trademark Films, & PW Productions and the Watermill Theatre and directed by Paul Hart, isn’t a dramatic making-of feature for an old BBC radio show. These include The Beatles (most notably their films, Christmas records to their fans and the B-side to Let It Be, You Know My Name (Look Up The Number), Monty Python (for whom Milligan cameoed in their film Life of Brian), Eddie Izzard, Douglas Adams, and many more. ![]() Spike is Spike Milligan, and this play gives us a glimpse into the man’s life through his creation and run of the Goon Show, a now often forgotten (and now often politically incorrect) 1950s radio comedy show which mostly lives on today, as the announcer concludes the show pointing out, through the people it has influenced. ![]() ![]() The game also lacks a map feature and forces you to backtrack throughout levels way too often. However, when there’s platforming involved, things become infuriating. That’s not really an issue during combat, as mashing the Square button like a lunatic will still be the solution to 99.99% of encounters. Sadly, despite featuring a great combat system, Narita Boy‘s controls are a bit confusing and feature a noticeable amount of input lag. That doesn’t mean the gameplay is flawless. ![]() You’ll crave for enemies to show up because it feels great just to tear them apart. Narita Boy nails the metroidvania progression system like few games do. You’ll constantly pick up new moves to increase your arsenal and it feels great. You can charge your sword attack in order to blast anyone near you with a home run bash and you can also use a limited supply of shots inside your blade, transforming it into a shotgun. ![]() Your sword packs one hell of a punch, transforming all kinds of enemies into piles of data. This the most anime Narita Boy ever gets, and it’s glorious. After a brief introductory section in which you’re unable to defend yourself against HIM’s minions, you’ll eventually grab the legendary Techno Sword and proceed to mow down everything in sight. Story-wise, Narita Boy isn’t very brilliant, but you can pretty much ignore it and enjoy the game for what it truly is: a super stylish metroidvania packed with tons of audiovisual elements taken straight from every single 80’s cliché you can imagine. You’ll also be greeted to a nonsensical amount of technobabble and invented terms that are here to basically make things even more incomprehensible than they already are. He is trying to save the land from the clutches of HIM (not related to the Finnish band) and restore the memories of the game’s creator, who takes the mantle of a god-like figure within the setting in a similar way to James Halliday in Ready Player One. Narita Boy‘s somewhat convoluted story revolves around the titular hero fighting through hordes of enemies inside a Digital Kingdom within an old-school computer game. Get ready for some seizures during this section. ![]() ![]() Prezi users can access a library of traditional icons and shapes, but they must find images from another source and upload them to the presentation. Prezi users should bear in mind that while the presentation structure is unique from other PowerPoint alternatives, Prezi templates aren’t very customizable-although presentations also can be designed from scratch. At the same time, it’s the perfect choice for presenters who want to design more creative presentations to capture audience attention. While Prezi offers a great alternative to traditional visual presentations, its unique design is better suited for more experienced presentation designers. Rather than the standard slide decks, Prezi users create animated, non-sequential presentations that zoom in to highlight topics and uncover subtopics. Prezi offers a different type of presentation software alternative to PowerPoint. Visme makes it simple to customize graphic content, insert videos and GIFs and even add audio to presentations. Visme users also enjoy a collection of thousands of icons, images and data visualizations like tables, graphs and flowcharts-all available from inside the editor. Visme users can choose to design their presentations from a blank canvas or by customizing templates from the alternative to PowerPoint’s library of sample slides and presentations. New content can be added with a simple drag and drop into place. The program is easy to use, as most elements can be moved around easily. Visme’s free alternative to PowerPoint can be used to design not only slide presentations, but also infographics, interactive charts and other visual content. Beautiful.ai has also added inspiration slides to our library of slide templates to help users from feeling stuck, as well as new intuitive controls to make our interface even easier to use. The 2021 release includes new presentation themes for design inspiration, extra presentation templates to help users get started on a professional-level design, and a universal search feature so users can explore the entire Beautiful.ai library of templates and presentations. The Beautiful.ai PowerPoint alternative even rolled out new features for 2021. Users also benefit from a vast library featuring thousands of free stock images, icons and logos, and they can add pizzazz to their presentations by customizing a variety of infographics or by adding eye-catching animations. Just add your content to the slide and let Beautiful.ai do the rest. Never again waste time aligning content, establishing margins or balancing fonts. What sets Beautiful.ai apart from its competition is what we like to call our special sauce- an artificially-intelligent platform that automatically tweaks your presentation based on the best design principles recommended by the pros. Our PowerPoint alternative presentation program is perfect for designing professional-level presentations in a fraction of the time it takes to create a PowerPoint slide deck. To help you out, we’ve narrowed the field down to- in no particular order- our favorite presentation programs similar to PowerPoint in 2021. ![]() ![]() ![]() ![]() Of course, it’s hard to know which you’ll prefer best without at least some basic information about the different alternative programs to PowerPoint. There’s no simple answer, either, since alternative programs to PowerPoint offer different features that meet various needs and preferences. When choosing the best alternative to PowerPoint presentation software, there are so many options that it can be hard to know which is better than the next. After all, you wouldn’t want your 2021 presentations to be so last year, right? We’ve created similar lists in 20, so it’s only fair if we offer readers a fresh list for a new year. Here at Beautiful.ai, we prefer looking ahead, and so we’ve compiled our annual list of the best PowerPoint alternatives to use in 2021. Whether making a personal list of New Year resolutions or a published list of top movies or biggest news stories of the past year, people worldwide are looking back on 2020, while also preparing for the year to come. The world has made yet another trip around the sun, and it’s the time of year when it seems like everybody is making a list. ![]() ![]() Larger and more expensive items are sent Parcelforce 48. You will receive an email as soon as your goods are dispatched.įor items under 2kg we normally dispatch via Royal Mail which arrives typically in 2-5 days. You will only pay for postage once and on the largest item. Our standard delivery is available from as little as £3.80. Most items ordered before 3pm Monday - Friday will be dispatched the same day. So when buying through our site, you can be sure that you are completely protected. In addition, you know that your session is in a secure encrypted environment when you see in the web address, and/or when you see the locked padlock symbol alongside the URL. Sage Pay is an active member of the PCI Security Standards Council (PCI SSC ) that defines card industry global regulation. They are also regularly audited by the banks and banking authorities to ensure that their systems are impenetrable. Sage Pay is PCI DSS (Payment Card Industry Data Security Standard) compliant to the highest level and maintains regular security audits. Once on the Sage Pay systems, all sensitive data is secured using the same internationally recognised 256-bit encryption standards. Sage Pay uses a range secure methods such as fraud screening, I.P address blocking and 3D secure. It is Sage Pay’s utmost priority to ensure that transaction data is handled in a safe and secure way. Sage Pay provides a secure payment gateway (Level 1 PCI DSS ), processing payments for thousands of online businesses, including ours. ![]() Our Payment Service Provider is Sage Pay (formerly Protx ) – the largest independent payment service provider (PSP ) in the UK and Ireland. ![]() ![]() The game is slated for worldwide release on multiple platforms, including mobile. FRONT MISSION 2089: Borderscape is head-produced by BlackJack Studio, the successful developers of Langrisser Mobile. By depicting the developmental process of the powerless under the fog of war, players will witness this world’s evolution together, using their understanding of helplessness to explore the roads to an inevitable tragedy. The vision for this new entry, FRONT MISSION 2089: Borderscape, focuses on the eve of the Second Huffman War and the escalating secret regional conflict. ![]() Supervised by Square Enix and developed by BlackJack Studio, FRONT MISSION 2089: Borderscape is a brand-new project set in the world of Square Enix’s legendary FRONT MISSION series. The stories about humanoid weapons and their pilots will unfold through battles intertwined with blood and tears. In this world, society is secretly puppeteered by a large federation composed of various countries, and constant regional conflicts have become the destructive norm. Front Mission 2089: Borderscape is being developed by BlackJack Studio, which also made Langrisser Mobile.As with previous Front Mission games, players can expect to be piloting or controlling the game’s giant mecha known as wanzers (from the German word Wanderpanzer, or walking tanks). ![]() Update 04/21/22 at 11:15 p.m.: Here is the official description of FRONT MISSION 2089: Borderscape from Square Enix, which notes that the game will be available on “multiple platforms” in addition to mobile:įRONT MISSION is a futuristic dystopian warfare-themed game series produced and published by Square Enix. ![]() ![]() ![]() The face of his necklace changes when it degrades.It is unknown how the Magnet Plant magnetizes the gold necklace, since the necklace is around his neck and gold is a non-magnetic metal.Various pieces of artwork depict his necklace as a circle with a flipped "Z" in the middle, but in-game, it is a golden skull.This is the most degrades of any plant or zombie in the entire franchise.Five of them are the hats being taken off, and the others are the necklace degrades and the zombie degrade. ![]()
![]() It doesn't matter how insanely CPU-intensive this sort of application is: some dipshit with no social insight and an underdeveloped sense of morality is going to deploy it in an attempt to monetize us. Once we combine procedural video generation with toolkits for promoting social media addiction and good old web tracking, we're on course to all be parasitized by our own AI stalkers, helpfully generating video and other content tweaked iteratively to compel us to pay attention, whether due to arousal, disgust, happiness, fear, or whatever. Forget troll armies harassing people they don't like by 'shopping their heads onto snuff movie victims and posting this on social media (so that if you naively go searching for person X, your first thousand hits are videos of person X committing horrific acts or being dismembered). The point is, we're close to going beyond simple recaptioning/keyword addition of pirated kids' cartoons, and getting into AI-assisted remixes of real people with TV/movies/game content, optimized to compel the viewer to watch it. Spamming YouTube keywords for ad revenue? Also possible. Maximizing views is easy if you decide to go for the shock value. It's possible the perpetrators don't speak or read English this is a side-effect of machine learning tools gone feral.) Most of the output was random gibberish, or inoffensive at worst: the same can't be said of "Keep Calm and Knife Her" or "Keep Calm and Rape A Lot". (This came up because some idiot wrote a bot to sell tee shirts via Amazon, with the caption "Keep Calm and " where are phrases some sort of machine learning system scraping lists of verbs and pronouns. (The preceding link is long and deeply creepy in its implications: it's a must-read.) And when algorithms go hog-wild to maximize eyeballs and/or sales you get weird and unpleasant results like this: The content and keywords on these ad-videos is largely algorithmically composed, and optimized for maximum eyeball draw. The political consequences of this toxic metastasis of "false news" I leave for discussion in comments.įor a while now there's been a very weird phenomenon on YouTube, whereby popular childrens videos are pirated, remixed, and reuploaded as advertising delivery vehicles. Everything becomes deniable, and in an age of state-sponsored infowar waged in social media it'll be trivially easy to discredit anyone. We can no longer believe the evidence of our own eyes and ears, unless we are in-person witnesses to a politician's speech. It'll probably be built into your smartphone's camera processor in a few years, first a "make me look fit in selfies" mode and then a "do the same thing, only in video chat" option.īut with procedural speech mimicry on top of face/body substitution, all video evidence turns questionable. Pretty soon everyone you see on film or TV is going to be 'shopped to look sexier, fitter, and skinnier than is actually natural. We can now automate the video-photoshopping of subjects so that, for example, folks like me don't look as unattractive in a talking-heads TV interview. And we all know about airbrushing/photoshopping of models on magazine covers and in adverts. It's a truism of the TV business that the camera adds ten kilograms. (Second generation application: Hitler sums it up, now with fewer subtitles) We need AI to get the lip-sync right, in other words, before today's simplistic AI-generated video porn turns really toxic. Being able to train a network to recognize the cadences of our target's intonation, though, and then to modulate a different speaker's words so they come out sounding right takes it into a whole new level of plausibility for human viewers, because we give credence to sensory inputs based on how consistent they are with our other senses. It's all very well to fake up a video of David Cameron fucking a goat, but without the bleating and mindless quackspeak it's pretty obvious that it's a fake. What I'm not seeing yet is the obvious application of this sort of deep learning to speech synthesis. ![]() ![]() ![]() In IEEE Symposium on Security and Privacy, 2013. An Ideal-Security Protocol for Order-Preserving Encoding. CLAMP: Practical Prevention of Large-Scale Data Leaks. Public-key Cryptosystems Based on Composite Degree Residuosity Classes. SCiFI - A System for Secure Face Identification. In IEEE Computer Security Foundations Symposium(CSF), 2012. Information-flow Control for Programming on Encrypted data. Flicker: An Execution Infrastructure for TCB Minimization. TrustVisor: Efficient TCB Reduction and Attestation. Fairplay - A Secure Two-Party Computation System. In IEEE Transactions on Image Processing, 2005. Fingerprinting Protocol for Images Based on Additive Homomorphic Property. In IEEE Computer Security Foundations Symposium, 2009. A Provably Secure And Efficient Countermeasure Against Timing Attacks. Making Linux Protection Mechanisms Egalitarian with UserFS. Faster Secure Two-Party Computation Using Garbled Circuits. TASTY: Tool for Automating Secure Two-partY computations. Flow-sensitive Pointer Analysis for Millions of Lines of Code. Implementing gentry0s fully-homomorphic encryption scheme. A Working Implementation of Fully Homomorphic Encryption. In 41st Annual ACM Symposium on Theory of Computing, 2009. Fully Homomorphic Encryption Using Ideal Lattices. Non-interactive verifiable computing: Outsourcing computation to untrusted workers. Information-flow Types for Homomorphic Encryptions. In Cryptology ePrint Archive, Report 2012/266. Compilation Techniques for Efficient Encrypted Computation. A Public-Key Cryptosystem and a Signature Scheme Based on Discrete Logarithms. A Lattice Model of Secure Information Flow. Asynchronous Multiparty Computation: Theory and Implementation. In Electronic Colloquium on Computational Complexity, 2011. Fully Homomorphic Encryption without Bootstrapping. Targeted Malleability: Homomorphic Encryption for Restricted Computations. Public Key Encryption with Keyword Search. Encrypted Domain DCT Based on Homomorphic Cryptosystems. FairplayMP: A System for Secure Multi-party Computation. Secure Content Sniffing for Web Browsers, or How to Stop Papers from Reviewing Themselves. Standards for the protection of personal information of residents of the commonwealth.Mcafee host intrusion prevention for server.We show that x86 code transformed with AutoCrypt achieves performance that is significantly better than its alternatives (downloading to a trusted client, or using fully-homomorphic encryption). Key to achieving this expressiveness over encrypted data, is our scheme to combine and convert between partially-homomorphic encryption (PHE) schemes using a small TCB in the trusted cloud hypervisor. We show that such a transformation is feasible for several standard Unix utilities available in a typical LAMP stack, with no developer effort. As a step towards this goal, we develop a tool called AutoCrypt, which transforms a subset of existing C functionality in the web stack to operate on encrypted sensitive content. In this context, the main challenge is to allow the legitimate functionality of the untrusted server VM to work. All sensitive web content is made available to the vulnerable server VM in encrypted form, thereby limiting the effectiveness of data-stealing attacks through server VM compromise. In this work, we investigate the feasibility of a web server architecture, wherein the vulnerable server VM runs on a trusted cloud. Web servers are vulnerable to a large class of attacks which can allow network attacker to steal sensitive web content. ![]() ![]() Sharon: What can you tell us about Murmur and where did that name come from? It satirizes modern society’s lust for fame and, in a grumpy old man, when-I-were-a-lad-things-were-much-better way, bemoans the rise of prefab music and what this means for our creativity. There are three interwoven stories: that of Jackie Thunder, a washed-up pop star who does something very stupid in an attempt to regain fame Gareth Jones, a misguided and supremely untalented young man who is killing celebrities and taping their tattoos to his body because he thinks he can gain their power by doing so, and thus stop himself turning completely invisible and Murmur, a demon who is directing Gareth behind the scenes for his own nefarious purposes. Michael : Wannabes is a big old genre mash-up: horror, fantasy and thriller held together with the stitching of satire. Working on the cover of Wannabes, which she also designed, was a bit more fraught at first, but we’ve managed to figure out how get it professional. ![]() ![]() Collaborating on the book with my wife has been fine. Michael: You could keep your keys, mobile phone, hankies, notebook, cigarettes, tablet, wallet and whatever other crap you have lying around in the bags under my eyes. Sharon: I got tired just reading all that! How has it been collaborating with your wife? I’m also working on a kids’ book with my wife, who is an artist, and forming a band with a friend. I’ve also spent a lot of time flipping back-and-forth between the many novels I want to write, and completely failing to decide which one to run with. Michael: I’ve been busy juggling my day job with finishing the Apocalypse Cow sequel and Wannabes, writing short stories, and dealing with two hectic kids (the baby of undetermined sex turned out to be an insane boy, who only stops breaking things when he decides it’s time to jam his hand down his nappy and fiddle with himself). ![]() |
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